US Practical guide1

Practical Guide

Rapid Progression Assessment for Patients With ADPKD- 2021 US Expert Opinion1

Definition of Rapid Progression

Reaching kidney failure by age 62*

Risk of Rapid Progression

Risk of reaching kidney failure by age 62 by estimating age-adjusted TKV:
Mayo Imaging Class 1 (typical bilateral renal cystic disease) C, D or E

Definition of Rapid Progression

Measured rapid growth of TKV or decline in kidney function due to cystic burden:

GFR decline ≥ 2.5 ml/min/year (over 5 years) and Class 1C-1E


TKV growth ≥ 5% per year (3 measurements at least 6 months apart)

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