Predicting Renal Outcome in Polycystic Kidney Disease (PROPKD) Scoring system predicts the likely hood of kidney failure before 60 years old.
Multivariate survival analysis identified four variables that were significantly associated with age at ESKD onset, and a scoring system from 0 to 9 was developed as follows:1
ADPKD patient info: 29 year old male with hypertension and a truncating PKD1 mutation
1 point for being male
2 points for hypertension before 35 years of age
4 points for a truncating PKD1 mutation
7 points PROPKD Score
HIGH Risk of Progression to ESKD
70.6 median age for ESKD onset
Eliminates evolution to ESKD before age 60†
†negative predictive value of 81.4%
56.9 median age for ESKD onset
49 median age for ESKD onset
Risk of rapid progression and a 92% chance of reaching kidney failure before age 60.
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