Case Profiles

Disease Progression Simulation

Select a hypothetical patient

Being male

Rapid kidney function decline*

Large kidney length measured by ultrasound†

High Blood Pressure at an early age

Events affecting the urinary tract (e.g. blood in the urine or lower back pain)

Family history of kidney failure by age 58

Large kidney volume compared to healthy kidneys

Other Risk Factors (e.g., Obesity)

*Confirmed eGFR decline ≥ 5 mL/min/1.73 m² within a year and/or ≥ 2.5 mL/min/1.73 m² per year over a period of five years.²

†When MRI-/CT-calculated TKV is not available, US-KL may be a useful surrogate when rapid progression is defined as CKD stage 3 development within 8 years.^2,3

ADPKD=autosomal dominant polycystic kidney disease; PKD=polycystic kidney disease; TKV=total kidney volume; US-KL=ultrasound kidney length; ESKD=end-stage kidney disease; eGFR=estimated glomerular filtration rate; MRI=magnetic resonance imaging; CT=computed tomography.

References:

1. Schrier RW, et al. Predictors of autosomal dominant polycystic kidney disease progression. J Am Soc Nephrol. 2014;25:2399-2418.

2. Gansevoort RT, et al. Recommendations for the use of tolvaptan in autosomal dominant polycystic kidney disease: a position statement on behalf of the ERA-EDTA Working Groups on Inherited Kidney Disorders and European Renal Best Practice. Nephrol Dial Transplant. 2016;31(3):337-48.

3. Bhutani H, et al. A comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease. Kidney Int. 2015;88:146-151.

The information provided on the ADPKDsim website is intended for your educational benefit only. It is not intended as, nor is it a substitute for medical care or advice or professional diagnosis.

Health care professionals should use their independent judgment when reviewing the ADPKDsim's educational resources. Users seeking medical advice should consult with a health care professional.

Disease Progression Simulation

Known Risk Factors

Known Risk Factors

Known Risk Factors

Known Risk Factors

Known Risk Factors