Prognostic Tools
There are a number of clinical risk factors associated with rapid disease progression in ADPKD. If one or more of these risk factors are present, different prognostic tools can be used to confirm the risk of rapid progression. Some of these prognostic tools can also assess how rapidly the disease may progress and even estimate time to ESRD.1-3
Select a tool below to learn more.
MRI/CT-calculated Total Kidney Volume
Clinical Risk Factors:
TKV greater than expected for age
How it works:
Uses simple MRI or CT kidney measurements to calculate TKV and determine low, intermediate or high risk for eGFR decline.
When is it appropriate?
For patients who have access to MRI or CT.4,5
PROPKD Score
Clinical Risk Factors:
Being male
Hypertension before age 35
Urologic events before age 35
Truncating
PKD1 mutation
How it works:
Tallies four risk factors to determine low, intermediate, or high risk for progression to ESRD.
When is it appropriate?
For patients who have genetic test results.6,7
ERA-EDTA Algorithm
Clinical Risk Factors:
Rapid historical eGFR decline*
Family history of ESRD by age 58
How it works:
Hierarchically evaluates risk factors to confirm likelihood of rapid disease progression.
When is it appropriate?
For patients with a variety of risk factors.2,7
Ultrasound Kidney Length
Clinical Risk Factors:
US-KL > 16.5 cm in patients less than 45 years of age†
How it works:
Can predict rapid disease progression in patients less than 45 years old.
When is it appropriate?
When MRI/CT-calculated TKV is not available.3,7