Prognostic Tools

Assessing the Rate of ADPKD Progression

MRI- or CT-calculated Total Kidney Volume (TKV)

Uses simple MRI or CT kidney measurements to calculate TKV and assess the risk of ADKPD progression.^1,2

TKV is the strongest available predictor of future renal insufficiency in ADPKD patients.*³ It only takes a few minutes to calculate TKV to predict future kidney growth and risk of eGFR decline.^1-3

View TKV Calculation

Other methods:

PROPKD Score

Tallies four variables to determine low, intermediate, or high risk for progression to ESRD.⁴

ERA-EDTA Algorithm

Hierarchically evaluates risk factors to determine likelihood of rapid disease progression.⁵

Ultrasound Kidney Length

Is a useful surrogate to assess risk for rapid disease progression when MRI/CT-calculated TKV is not available.³

*with a Typical (Class 1) presentation

ADPKD=autosomal dominant polycystic kidney disease; MRI=magnetic resonance imaging; CT=computed tomography; TKV=total kidney volume; eGFR=estimated glomerular filtration rate; PKD=polycystic kidney disease; ESRD=end-stage renal disease; ERA-EDTA=European Renal Association – European Dialysis and Transplant Association.

References:

1. Higashihara E, et al. Kidney volume estimations with ellipsoid equations by magnetic resonance imaging in autosomal dominant polycystic kidney disease. Nephron. 2015;129:253-262.

2. Irazabal MV, et al. Imaging classification of autosomal dominant polycystic kidney disease: a simple model for selecting patients for clinical trials. J Am Soc Nephrol. 2015;26:160-172.

3. Bhutani H, et al. A comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease. Kidney Int. 2015;88:146-151.

4. Cornec-Le Gall E, et al. The PROPKD score: a new algorithm to predict renal survival in autosomal dominant polycystic kidney disease. J Am Soc Nephrol. 2016;27(3):942-951.

5. Gansevoort RT, et al. Nephrol Dial Transplant. 2016;31:337-348.

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Assessing the Rate of ADPKD Progression