Prognostic Tools

Clinical Risk Factors and Prognostic Tools

There are a number of clinical risk factors associated with rapid disease progression in ADPKD. If one or more of these risk factors are present, different prognostic tools can be used to confirm the risk of rapid progression. Some of these prognostic tools can also assess how rapidly the disease may progress and even estimate time to ESRD.1-3

Select a tool below to learn more.

MRI/CT-calculated Total Kidney Volume Icon

Clinical Risk Factors:

  • TKV greater than expected for age

    TKV greater than expected for age

How it works:

Uses simple MRI or CT kidney measurements to calculate TKV and determine low, intermediate or high risk for eGFR decline.

When is it appropriate?

For patients who have access to MRI or CT.4,5

PROPKD Score Icon

Clinical Risk Factors:

  • Being male

    Being male

  • Hypertension before age 35

    Hypertension before age 35

  • Urologic events before age 35

    Urologic events before age 35

  • Truncating PKD1 mutation

    Truncating
    PKD1 mutation

How it works:

Tallies four risk factors to determine low, intermediate, or high risk for progression to ESRD.

When is it appropriate?

For patients who have genetic test results.6,7

Algorithm Flowchart Icon

Clinical Risk Factors:

  • eGFR decline 5 mL/min/1.73 m2 within a year

    Rapid historical eGFR decline*

  • Family history of ESRD by age 58

    Family history of ESRD by age 58

How it works:

Hierarchically evaluates risk factors to confirm likelihood of rapid disease progression.

When is it appropriate?

For patients with a variety of risk factors.2,7

Ultrasound Kidney Length Icon

Clinical Risk Factors:

  • US-KL > 16.5 cm in patients less than 45 years of age†

    US-KL > 16.5 cm in patients less than 45 years of age†

How it works:

Can predict rapid disease progression in patients less than 45 years old.

When is it appropriate?

When MRI/CT-calculated TKV is not available.3,7