US-KL alone can be used to determine whether there is risk of rapid disease progression in ADPKD.*1
MRI is the recommended imaging modality for the most accurate and reproducible measurement of kidney length, kidney cyst burden, and TKV. As such, MRI/CT-calculated TKV is a strong predictor of future renal insufficiency in ADPKD. However, US-measured KL is a useful surrogate when MRI/CT-calculated TKV is not feasible.1
US-measured predictor of rapid progression† KL > 16.5 cm in patients less than 45 years old
†when rapid progression is defined as CKD stage 3 development within 8 years1,2
*Based on data analysis comparing baseline US and MRI KL measurements from the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP)1
ADPKD=autosomal dominant polycystic kidney disease; MRI=magnetic resonance imaging; TKV=total kidney volume; CT=computed tomography; CKD=chronic kidney disease.
1. Bhutani H, et al. A comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease. Kidney Int. 2015;88:146-151.
2. Gansevoort RT, et al. Nephrol Dial Transplant. 2016;31:337-348.
3. Chebib FT, et al. J Am Soc Nephrol. 2018;29(10):2458-2470.
4. Magistroni R, et al. A review of the imaging techniques for measuring kidney and cyst volume in establishing autosomal dominant polycystic kidney disease progression. Am J Nephrol. 2018;48:67-78.