Multivariate survival analysis identified four variables that were significantly associated with age at ESRD onset, and a scoring system from 0 to 9 was developed as follows:1
PROPKD Calculator
ADPKD patient info: 29 year old male with hypertension and a truncating PKD1 mutation
1 point for being male
2 points for hypertension before 35 years of age
4 points for a truncating PKD1 mutation
7 points PROPKD Score
HIGH Risk of Progression to ESRD
70.6 median age for ESRD onset
Eliminates evolution to ESRD before age 60†
†negative predictive value of 81.4%
56.9 median age for ESRD onset
49 median age for ESRD onset
Forecasts ESRD onset before age 60‡
‡positivepredictive value of 90.9%