PROPKD Score

Multivariate survival analysis identified four variables that were significantly associated with age at ESRD onset, and a scoring system from 0 to 9 was developed as follows:1

PROPKD Calculator

Variable
Points
being male
1
hypertension before 35 years of age
2
first urologic event* before 35 years of age
2
mutation
PKD2 mutation
0
nontruncating PKD1 mutation
2
truncating PKD1 mutation
4
PROPKD Score =
SUM

Sample PROPKD Score Calculation

ADPKD patient info: 29 year old male with hypertension and a truncating PKD1 mutation

1 point for being male

2 points for hypertension before 35 years of age

4 points for a truncating PKD1 mutation


7 points PROPKD Score

HIGH Risk of Progression to ESRD

Total Points: PROPKD Score
Risk of Progression to ESRD
0
1
2
3

LOW

70.6 median age for ESRD onset

Eliminates evolution to ESRD before age 60

negative predictive value of 81.4%

4
5
6

INTERMEDIATE

56.9 median age for ESRD onset

7
8
9

HIGH

49 median age for ESRD onset

Forecasts ESRD onset before age 60

positivepredictive value of 90.9%

PROPKD Calculator